Sinugrandisterols A–D, trihydroxysteroids from the soft coral Sinularia grandilobata

详细信息	查看全文 | 推荐本文 |

• 作者：Atallah F. Ahmed ; Shu-Hui Tai ; Yang-Chang Wu ; Jyh-Horng Sheu
• 关键词：Trihydroxysteroids ; Sinularia grandilobata ; Cytotoxicity
• 刊名：Steroids
• 出版年：2007
• 期刊代码：142_0039128x
• 类别：bio
• 出版时间：April 2007
• 卷：72
• 期：4
• 页码：368-374
• 文件大小：503 K

摘要

Four new trihydroxysteroids, sinugrandisterols A–D (1–4), have been isolated from the CH₂Cl₂-soluble fraction of the EtOH extract of Sinularia grandilobata. The structures of these metabolites were determined on the basis of spectroscopic (IR, MS, and 1D and 2D NMR) analysis. The cytotoxicity of 1–4 toward a limited panel of cancer cell lines is also reported.