Quantifying cerebellar atrophy in multiple system atrophy of the cerebellar type (MSA-C) using three-dimensional gyrification index analysis

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• 作者：Yu-Te Wu^a ; ^b ; ^c ; ¹ ; Kuo-Kai Shyu^d ; ¹ ; Chii-Wen Jao^d ; ^e ; Yuan-Lin Liao^f ; Tzu-Yun Wang^a ; Hsiu-Mei Wu^g ; Po-Shan Wang^h ; ⁱ ; ^j ; ^k ; ^{b8001071@yahoo.com.tw} ; Bing-Wen Soong^h ; ^j ;
• 关键词：Atrophy ; Cerebellum ; Gyrification index ; MSA-C
• 刊名：NeuroImage
• 出版年：2012
• 期刊代码：83_10538119
• 类别：neu
• 出版时间：15 May, 2012
• 卷：61
• 期：1
• 页码：1-9
• 文件大小：875 K

摘要

Multiple system atrophy of the cerebellar type (MSA-C) is a degenerative neurological disease of the central nervous system. This study employed a method named, 鈥渟urface-based three-dimensional gyrification index鈥?(3D-GI) to quantify morphological changes in normal cerebellum (including brainstem) and atrophied cerebellum, in patients with MSA-C. We assessed whether 3D-GI can exclude gender and age differences to quantify cerebellum and brainstem atrophy more accurately. Sixteen healthy subjects and 16 MSA-C patients participated in this study. We compared 3D-GI values and volumes in the cerebellum, based on T1-weighted MR images. We also compared the images of reconstructed 3D cerebellum gray matter (3D-CBGM) and cerebellum white matter (3D-CBWM) to detect the atrophied cerebellar region in MSA-C patients. The 3D-GI values were in a stable range with small variances, exhibiting no gender effect and no age-related shrinkage. Significantly lower 3D-GI values were exhibited in both CBGM and CBWM of the MSA-C patients compared with healthy subjects, even in the early phases of the disease. Decreases in 3D-GI values indicated the degeneration of the cerebellar folding structure, exactly reflecting the morphological changes in cerebellum. The 3D-GI method based on CBGM resulted in superior discriminative accuracy compared with the CBGM volumetric method. Using the two-dimensional 3D-GI values, the K-means classifier can evidently discriminate the MSA-C patients from healthy subjects.