Does treatment affect the levels of serum Interleukin-6, Interleukin-8 and procalcitonin in diabetic foot infection? A pilot study

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• 作者：Fatma Aybala Altay^a ; ^{altay_mustafa@hotmail.com} ; 陌rfan 艦encan^a ; Gö ; nü ; l Ç ; iç ; ek 艦entü ; rk^a ; Mustafa Altay^b ; Selda Gü ; venman^c ; Selman Ü ; nverdi^d ; Ziya Cibali Aç ; 谋kgö ; z^c
• 关键词：Diabetic foot infection ; Procalcitonin ; IL-6 ; IL-8
• 刊名：Journal of Diabetes and its Complications
• 出版年：2012
• 期刊代码：154_10568727
• 类别：med
• 出版时间：May-June, 2012
• 卷：26
• 期：3
• 页码：214-218
• 文件大小：253 K

摘要

Aims

To investigate about serum PCT, IL-6 and IL-8 levels and how they are affected by the treatment in diabetic foot patients.

Methods

Fifty patients鈥?blood samples were taken to study ESR and CRP, IL-6, IL-8 and PCT before and at the 14th day of the treatment.

Results

The pretreatment results of the 50 patients showed positive correlations between PCT and either ESH (r = 0.49, p < 0.001), or CRP (r = 0.56, p < 0.001). Similarly, there was a positive correlation between IL-6 and ESH (r = 0.46, p = 0.001), just like as it was between IL-6 and CRP (r = 0.54, p < 0.001). At the 14th day, the levels of ESR (70 卤 30.2 and 58.4 卤 26.2, p = 0.02), CRP (63.8 卤 73.1 and 18.1 卤 19.7, p < 0.001) and PCT (0.6 卤 2.1 and 0.05 卤 0.02, p = 0.007) were significantly decreased while IL-6 was decreased at a close range to statistical significancy at healing patients (97.5 卤 147.2 and 47.1 卤 77.6; p = 0.05), but they did not at nonhealing patients. IL-8 levels were not changed anyhow.

Conclusions

PCT was significantly decreased such as ESR and CRP were in the early phase of healing; IL-6 and IL-8 levels were also decreased by the treatment, but not statistically significantly. IL-6 and PCT were affected in correlation with the other inflammatory parameters in the beginning, but IL-8 was not. PCT and IL-6 may be useful like CRP and ESR in the diagnosis and follow up of diabetic foot infection, but IL-8 is not. Further investigation is needed.