Admission levels of soluble CD137 are increased in patients with acute pancreatitis and are associated with subsequent complications

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• 作者：Zhe Shao^a ; ¹ ; Andreas Schä ; ffler^b ; ¹ ; Okka Hamer^c ; Judith Dickopf^b ; Andrea Goetz^b ; Karin Landfried^b ; Markus Voelk^c ; Andrea Kopp^b ; Hans Herfarth^d ; Thomas Karrasch^b ; Tanja Brü ; nnler^b ; Liang Kai Koh^a ; Christa Buechler^b ; Herbert Schwarz^a ; ^e ; ^{phssh@nus.edu.sg}
• 关键词：APACHE-II score ; Acute Physiology And Chronic Health Evaluation II score ; ERCP ; endoscopic retrograde cholangiopancreatography ; LDH ; lactate dehydrogenase ; sCD137 ; soluble CD137
• 刊名：Experimental and Molecular Pathology
• 出版年：2012
• 期刊代码：291_00144800
• 类别：med
• 出版时间：February, 2012
• 卷：92
• 期：1
• 页码：1-6
• 文件大小：494 K

摘要

The progression of acute pancreatitis to necrotizing pancreatitis which often results in high morbidity and mortality is difficult to predict. Here we report that serum concentrations of sCD137 are increased in patients with acute pancreatitis. Admission levels and 10-day median sCD137 levels positively correlate with markers of biliary pancreatitis and the 10-day sCD137 median is significantly higher in metabolic than in alcoholic pancreatitis. Serum concentrations of sCD137 at time of admission and the 10-day median of sCD137 correlate with the Ranson and APACHE II disease scores but not with the radiological Balthazar and Schroeder scores that reflect pancreatic and peripancreatic necrosis. Further, sCD137 levels correlate with the probability of complications and lethality. The association of sCD137, a product of activated T cells, with the severity of acute pancreatitis suggests that T cells contribute to the pathogenesis of acute pancreatitis.