A dynamic model for induced reactivation of latent virus
- 作者：G.M. Kepler ; H.K. Nguyen ; J. Webster-Cyriaque ; H.T. Banks
- 关键词：Reactivation of latent virus ; Mathematical model ; KSHV ; Herpes virus
- 刊名：Journal of Theoretical Biology
- 出版年：2007
- 期刊代码：79_00225193
- 类别：mt
- 出版时间：7 February 2007
- 卷：244
- 期：3
- 页码：451-462
- 文件大小：272 K
摘要
We develop a deterministic mathematical model to describe reactivation of latent virus by chemical inducers. This model is applied to the reactivation of latent KSHV in BCBL-1 cell cultures with butyrate as the inducing agent. Parameters for the model are first estimated from known properties of the exponentially growing, uninduced cell cultures. Additional parameters that are necessary to describe induction are determined from fits to experimental data from the literature. Our initial model provides good agreement with two independent sets of experimental data, but also points to the need for a new class of experiments which are required for further understanding of the underlying mechanisms.