Synthesis and characterization of bioactive glasses functionalized with Cu nanoparticles and organic molecules

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• 作者：A. Bonici ; G. Lusvardi ; ^{gigliola.lusvardi@unimore.it} ; G. Malavasi ; L. Menabue ; A. Piva
• 关键词：Sol&ndash ; gel glass ; Copper ; Nano-particles ; Bioactive glasses ; Functionalization
• 刊名：Journal of the European Ceramic Society
• 出版年：2012
• 期刊代码：53_09552219
• 类别：ms
• 出版时间：August, 2012
• 卷：32
• 期：11
• 页码：2777-2783
• 文件大小：640 K

摘要

Bioactive sol gel glasses, based on the ternary system 15CaO路5P₂O₅路80SiO₂, doped with Cu were synthesized and characterized in order to define the oxidation state of Cu as a function of thermal treatments. In particular, we were able to optimize the condition to obtain: (i) the reduction of Cu²⁺ to Cu⁰ followed by nano-aggregation of metal nano-particles (MeNPs) into glass matrix; (ii) a mixed Cu²⁺/Cu⁺/Cu⁰ NPs-containing glasses; (iii) a Cu²⁺-containing glasses.

Successively, the surface of sol-gel glasses was functionalized by means of organic molecules (amino and mercapto alcohols) to give rise to a system that can interact with the functional groups of the drugs. The functionalization was carried out as a function of the sol-gel glass composition, organic molecules concentration and temperature of the process; the results indicate a preference for the amino groups. The bioactivity (formation of an apatitic layer after simulated body fluid SBF test) was verified for the functionalized sol-gel Cu²⁺-containing glasses and they are still bioactive.