Interferon Regulatory Factor 1 (IRF-1) induces p21^WAF1/CIP1 dependent cell cycle arrest and p21^WAF1/CIP1 independent modulation of survivin in cancer cells

详细信息	查看全文 | 推荐本文 |

• 作者：Michaele J. Armstrong^a ; Michael T. Stang^a ; Ye Liu^a ; Jinbo Gao^a ; Baoguo Ren^a ; Brian S. Zuckerbraun^a ; Raja S. Mahidhara^a ; Quanhua Xing^e ; Eva Pizzoferrato^b ; ^c ; ^d ; ¹ ; John H. Yim^e ; ¹ ; ^jyim@coh.org
• 关键词：IRF-1 ; Survivin ; p21 ; Cell cycle ; Cancer
• 刊名：Cancer Letters
• 出版年：2012
• 期刊代码：44_03043835
• 类别：med
• 出版时间：1 June, 2012
• 卷：319
• 期：1
• 页码：56-65
• 文件大小：886 K

摘要

We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protein (IAP) survivin and the induction of the cyclin-dependent kinase inhibitor p21^WAF1/CIP1. In this report, we investigated the direct role of p21 in the suppression of survivin. We show that IRF-1 down-regulates cyclin B1, cdc-2, cyclin E, E2F1, Cdk2, Cdk4, and results in p21-mediated G1 cell cycle arrest. Interestingly, while p21 directly mediates G1 cell cycle arrest, IRF-1 or other IRF-1 signaling pathways may directly regulate survivin in human cancer cells.