Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis

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• 作者：Mustafa Kas谋m Karahocagil^a ; Mehmet Aslan^b ; ^{m.aslan301@mynet.com} ; Mehmet Resat Ceylan^a ; Aytekin C谋kman^c ; Mahmut Sunnetcioglu^a ; Mehmet Emin Kucukoglu^b ; Abdullah Task谋n^d
• 关键词：Acute brucellosis ; Myeloperoxidase activity ; Catalase activity ; Oxidative stress ; Atherosclerosis
• 刊名：Clinical Biochemistry
• 出版年：2012
• 期刊代码：55_00099120
• 类别：med
• 出版时间：July, 2012
• 卷：45
• 期：10-11
• 页码：733-736
• 文件大小：151 K

摘要

Objectives

The role of infection in the pathogenesis of atherosclerosis has been increasingly discussed. Previous studies have suggested that increased myeloperoxidase activity plays an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the serum myeloperoxidase activity and catalase activity along with lipid hydroperoxide (LOOH) levels in patients with acute brucellosis.

Design and methods

Thirty-two patients with brucellosis and 33 healthy controls were enrolled. Serum myeloperoxidase activity, catalase activity and LOOH levels were determined.

Results

Serum myeloperoxidase activity and LOOH levels were significantly higher in patients with brucellosis than controls (p < 0.05, p < 0.001), while catalase activity were significantly lower (p < 0.001). LOOH levels were found to be significantly positively correlated with MPO activity (r = 0.297, p = 0.016) in patients.

Conclusions

These results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients.