Hippocampal N-Acetyl Aspartate in Unaffected Siblings of Patients with Schizophrenia: A Possible Intermediate Neurobiological Phenotype
- 作者：Callicott ; Joseph H. ; Egan ; Michael F. ; Bertolino ; Alessandro ; Mattay ; Venkata S. ; Langheim ; Frederick J.P. ; et. al.
- 关键词：Schizophrenia ; sibling ; spectroscopy ; endophenotype ; prefrontal ; glutamate
- 刊名：Biological Psychiatry
- 出版年：1998
- 期刊代码：34_00063223
- 类别：med
- 出版时间：November 15, 1998
- 卷：44
- 期：10
- 页码：941-950
- 文件大小：960 K
摘要
Background: Shared neurobiological characteristics of patients with schizophrenia and their siblings may represent “intermediate phenotypes” that may more closely reflect the genetic susceptibility underlying this illness. We sought evidence of such phenotypes using magnetic resonance spectroscopy based on previously described regional abnormalities in levels of the neuronal marker N-acetyl-aspartate (NAA) in the hippocampal area and dorsolateral prefrontal cortex of patients with schizophrenia.