Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors
- 作者：Jun-Ichi Sakamoto ; Tetsuo Koyama ; Daisei Miyamoto ; Sangchai Yingsakmongkon ; Kazuya I.P.J. Hidari ; Wipawee Jampangern ; Takashi Suzuki ; Yasuo Suzuki ; Yasuaki Esumi ; Ken Hatano ; et al.
- 关键词：Thioglycosides ; Enzyme inhibitors ; Sialic acid ; Influenza virus ; Sialidases ; Glycoclusters
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：1 February 2007
- 卷：17
- 期：3
- 页码：717-721
- 文件大小：164 K
摘要
An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with α-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases.