Cardiovascular and metabolic risk in outpatients with schizoaffective disorder treated with antipsychotics: Results from the CLAMORS study

详细信息	查看全文 | 推荐本文 |

• 作者：J. Bobes^a ; ^{bobes@uniovi.es} ; C. Arango^b ; P. Aranda^c ; R. Carmena^d ; M. Garcia-Garcia^e ; J. Rejas^f ; on behalf of the CLAMORS Study Collaborative Group¹
• 关键词：Metabolic syndrome ; Cardiovascular risk ; Schizoaffective disorders ; Outpatients ; Antipsychotic treatment ; Mental status
• 刊名：European Psychiatry
• 出版年：2012
• 期刊代码：96_09249338
• 类别：med
• 出版时间：May, 2012
• 卷：27
• 期：4
• 页码：267-274
• 文件大小：581 K

摘要

Aim

To assess the coronary heart disease (CHD) risk and prevalence of the metabolic syndrome (MS) in patients with schizoaffective disorder (SD) receiving antipsychotics.

Methods

Patients meeting DSM-IV criteria for SD and receiving antipsychotic treatment were recruited in a retrospective, cross-sectional, multicenter study (the CLAMORS study). MS was defined as at least three of the following components: waist circumference greater than 102 cm (men)/greater than 88 cm (women); serum triglycerides greater or equal to 150 mg/dl; HDL cholesterol less than 40 mg/dl (men)/less than 50 mg/dl (women); blood pressure greater or equal to 130/85 mmHg; fasting blood glucose greater or equal to 110 mg/dl. The 10-year CHD risk was assessed by the Systematic coronary risk evaluation (SCORE) (cardiovascular mortality) and Framingham (any cardiovascular event) functions. Clinical severity was assessed using the PANSS and CGI-S scales.

Results

A total of 268 valuable patients with SD (127聽men, 48.1%), 41.9 卤 12.3 years (mean 卤 S.D.), were analyzed. The 10-year overall cardiovascular mortality and CV-event risk were 0.8 卤 1.6 (SCORE) and 6.5 卤 6.8 (Framingham), respectively. A high/very high risk of any CV event (Framingham 鈮?#xA0;10%) was associated with severity [CGI-S = 3-4; OR: 4.32 (1.15-16.26), P = 0.03)]. MS was present in 26.5%(95%CI: 21.2-31.8) of subjects, without gender differences, but significantly associated with patient's impression of severity: CGI = 3-4; OR = 1.90 (0.83-4.36), and CGI = 5-7; OR = 3.13 (1.06-9.24), P = 0 < 0.001, and age [OR = 1.91 (1.09-3.34), P < 0.024)].

Conclusions

CHD risk and MS prevalence were high among patients with SD, being MS prevalence associated with age and severity of disease.