• 作者：Jesú ; s Millá ; n Nú ; ñ ; ez-Cort&#233 ; s^a ; ^b ; ^{jesus.millan@salud.madrid.org} ; Luis Alvarez-Sala Walther^a ; ^b ; Carlos Recarte Garcia-Andrade^a ; ^b ; Maria Ferrer Civeira^a ; Granada Alvarez Nov&#233 ; s^c ; Ysmael Alvarez Rodriguez^c
• 关键词：Efectos pleiotró ; picos ; Estatinas ; Actina
• 刊名：Cl篓陋nica e Investigaci篓庐n en Arteriosclerosis
• 出版年：2012
• 期刊代码：pca88_02149168
• 类别：med
• 出版时间：May-June, 2012
• 卷：24
• 期：3
• 页码：147-153
• 文件大小：1394 K

3-HMG-CoA-reductase inhibitors (statins) are drugs which have been widely demonstrated to have clinical benefits in the prevention of cardiovascular diseases. Some of these benefits, particularly those that may take place immediately, are due to effects that may be independent of the decrease in cholesterol and LDL-cholesterol levels. These effects are known as pleiotropic effects.

In the present study, using cultures of the cells involved in the atherogenic process: fibroblasts, monocytes, endothelial cells and smooth muscle cells submitted to different types and doses of statins, we have attempted to demonstrate the changes in cell behaviour.

Our results support the idea that subsequent changes are produced on the addition of statins into the culture medium, and which affect cell adhesiveness, as well as mobility and. in the case of smooth muscle cells, the contractility. These changes may explain, at least partly, some of the effects other than those directly related to the lipid lowering effect. Behind such changes may be found alterations in intracellular metabolism.