Rise of cytosolic Ca²⁺ and activation of membrane-bound guanylyl cyclase activity in rat enterocytes by heat-stable enterotoxin of Vibrio cholerae non-01

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• 作者：Ghosh Chaudhuri ; Alok ; Bhattacharya ; Jayanta ; Nair ; G. Balakrish ; Takeda ; Tae ; Chakrabarti ; Manoj K.
• 关键词：Vibrio cholerae non-01 ; Heat-stable enterotoxin ; Intracellular calcium ion concentration ; Guanylyl cyclase ; Epithelial cell
• 刊名：FEMS Microbiology Letters
• 出版年：1998
• 期刊代码：34_03781097
• 类别：imm
• 出版时间：March 1, 1998
• 卷：160
• 期：1
• 页码：125-129
• 文件大小：308 K

摘要

The cytosolic calcium level ([Ca²⁺]_i) and the membrane-bound guanylyl cyclase activity in the isolated rat intestinal epithelial cells were investigated. Heat-stable enterotoxin of Vibrio cholerae non-01 (NAG-ST) was found to increase both the [Ca²⁺]_i and the enzyme activity. These changes occur similarly until 5 min of incubation with NAG-ST, indicating that these changes might be involved in NAG-ST induced signal transduction in rat enterocytes.