Pharmacological approach to the treatment of long and short QT syndromes
- 作者：Chinmay Patel ; Charles Antzelevitch
- 关键词：Sudden cardiac death ; Arrhythmias ; Electrophysiology ; Pharmacology Inherited channelopathy
- 刊名：Pharmacology and Therapeutics
- 出版年：2008
- 期刊代码：41_01637258
- 类别：pha
- 出版时间：April 2008
- 卷：118
- 期：1
- 页码：138-151
- 文件大小：673 K
摘要
Inherited channelopathies have received increasing attention in recent years. The past decade has witnessed impressive progress in our understanding of the molecular and cellular basis of arrhythmogenesis associated with inherited channelopathies. An imbalance in ionic forces induced by these channelopathies affects the duration of ventricular repolarization and amplifies the intrinsic electrical heterogeneity of the myocardium, creating an arrhythmogenic milieu. Today, many of the channelopathies have been linked to mutations in specific genes encoding either components of ion channels or membrane or regulatory proteins. Many of the channelopathies are genetically heterogeneous with a variable degree of expression of the disease. Defining the molecular basis of channelopathies can have a profound impact on patient management, particularly in cases in which genotype-specific pharmacotherapy is available.