Postoperative adjuvant transcatheter arterial chemoembolisation improves survival of intrahepatic cholangiocarcinoma patients with poor prognostic factors: Results of a large monocentric series

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• 作者：Z.F. Wu ; H.B. Zhang ; N. Yang ; W.C. Zhao ; Y. Fu ; G.S. Yang ; ^{lacent1981@126.com}
• 关键词：Intrahepatic cholangiocarcinoma ; Curative resection ; Adjuvant TACE ; Prognostic factor
• 刊名：European Journal of Surgical Oncology (EJSO)
• 出版年：2012
• 期刊代码：121_07487983
• 类别：med
• 出版时间：July, 2012
• 卷：38
• 期：7
• 页码：602-610
• 文件大小：361 K

摘要

Background

The prognosis of patients with intrahepatic cholangiocarcinoma (ICC) is currently unsatisfactory. The aims of this study were to identify prognostic factors after curative ICC resection, and to evaluate the effects of postoperative transcatheter arterial chemoembolisation (TACE).

Methods

A retrospective analysis was conducted of 114 ICC patients who underwent curative resection from January 2005 to December 2006. Relationships between survival and clinicopathological factors were evaluated using univariate and multivariate analyses. The benefits of adjuvant TACE were investigated separately.

Results

The cumulative 1-, 3-, and 5-year survival rates were 63%, 26%, and 15%, respectively. Multivariate analysis revealed that tumour size 鈮? cm (hazard ratio [HR] 1.875, 95%CI 1.139-3.088, P = 0.013) and advanced TNM stage (stage III or IV) (HR 1.681, 95%CI 1.035-2.732, P = 0.036) were independently associated with poor prognosis. Fifty-seven patients underwent adjuvant TACE. In patients with poor prognostic factors, TACE improved the survival rate (P < 0.001). However, in patients without poor prognostic factors, TACE did not significantly change the survival rate (P = 0.724).

Conclusions

Postoperative adjuvant TACE can prolong survival in ICC patients with tumour size 鈮? cm or advanced TNM stage.