Genomic analysis of ICEVchBan8: An atypical genetic element in Vibrio cholerae

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• 作者：Elisa Taviani^a ; ¹ ; Matteo Spagnoletti^b ; ¹ ; Daniela Ceccarelli^b ; Bradd J. Haley^a ; Nur A. Hasan^a ; Arlene Chen^a ; Mauro M. Colombo^b ; Anwar Huq^a ; Rita R. Colwell^c ; ^d ; ^{rcolwell@umiacs.umd.edu}
• 关键词：Integrative conjugative elements ; Genomic islands ; Lateral gene transfer ; Vibrio cholerae
• 刊名：FEBS Letters
• 出版年：2012
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：4 June, 2012
• 卷：586
• 期：11
• 页码：1617-1621
• 文件大小：608 K

摘要

Genomic islands (GIs) and integrative conjugative elements (ICEs) are major players in bacterial evolution since they encode genes involved in adaptive functions of medical or environmental importance. Here we performed the genomic analysis of ICEVchBan8, an unusual ICE found in the genome of a clinical non-toxigenic Vibrio cholerae O37 isolate. ICEVchBan8 shares most of its genetic structure with SXT/R391 ICEs. However, this ICE codes for a different integration/excision module is located at a different insertion site, and part of its genetic cargo shows homology to other pathogenicity islands of V. cholerae.