A reliable synthesis of 2- and 6-amino-β-cyclodextrin and permethylated-β-cyclodextrin

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• 作者：I. Wayan Muderawan ; Teng Teng Ong ; Teck Chia Lee ; David J. Young ; Chi Bun Ching and Siu Choon Ng
• 关键词：Modified cyclodextrin ; Amino β ; -cyclodextrin ; Amino permethyl-β ; -cyclodextrin
• 刊名：Tetrahedron Letters
• 出版年：2005
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：2005
• 卷：46
• 期：46
• 页码：7905-7907
• 文件大小：102 K

摘要

A new, reliable method for the introduction of an amine group at positions 2 or 6 of β-cyclodextrin and permethyl-β-cyclodextrin is described. It involves selective tosylation followed by azide substitution and almost quantitative reduction with triphenylphosphine followed by hydrolysis of the phosphinimine intermediate.