Enantioselective separation in capillary electrophoresis using a novel mono-6^A-propylammonium-β-cyclodextrin as chiral selector

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• 作者：Weihua Tang ; I. Wayan Muderawan ; Siu-Choon Ng and Hardy Sze On Chan
• 关键词：Enantionmeric separation ; Cationic β ; -cyclodextrin ; Capillary electrophoresis ; 6^A-Propylammonium-6^A-deoxy-β ; -cyclodextrin chloride
• 刊名：Analytica Chimica Acta
• 出版年：2006
• 期刊代码：2_00032670
• 类别：ch
• 出版时间：5 January 2006
• 卷：555
• 期：1
• 页码：63-67
• 文件大小：294 K

摘要

The chiral resolving ability of a novel single-isomer cationic β-cyclodextrin (CD), mono-6^A-propylammonium-6^A-deoxy-β-cyclodextrin chloride (PrAMCD), as a chiral selector in capillary electrophoresis (CE) is reported in this work for the enantioseparation of hydroxy, carboxylic acids and amphoteric analytes. The effect of chiral selector concentration on the resolution was studied. Good resolutions were achieved for hydroxy acids. Optimum resolutions were obtained even at 3.5 mM CD concentration for carboxylic acids. The electrophoretic method showed good linearity and reproducibility in terms of migration times and peak areas, which should make it suitable for routine analysis. In addition, baseline chiral separation of a six-acid mixture was achieved within 20 min. PrAMCD proved to be an effective chiral selector for acidic analytes.