• 作者：A. Borrá ; s-Verdera^a ; ^{aurelioborras@telefonica.net} ; V. Calcedo-Bernal^b ; J. Ojeda-Levenfeld^b ; C. Clavel-Sainz^c
• 关键词：Á ; cido hialuró ; nico ; Infiltració ; n ; Osteartritis ; Condroprotecció ; n
• 刊名：Revista Espa帽ola de Cirug铆a Ortop茅dica y Traumatolog铆a
• 出版年：2012
• 期刊代码：pca311_18884415
• 类别：med
• 出版时间：July-August, 2012
• 卷：56
• 期：4
• 页码：274-280
• 文件大小：337 K

Objective

To evaluate the safety and efficacy of a single intra-articular injection of 2%hyaluronic acid (HA) + mannitol in symptomatic knee osteoarthritis (KOA).

Material and methods

Pilot, multicentre, open, non-comparative study performed in eighty patients with painful KOA, of whom 79 completed the study. They received one injection of 2 ml of 2%HA + 0.5%mannitol (Day 0) and were followed-up for 6 months. On Days 0, 15, 30, 60, 90, 120, 150 and 180, pain and joint function were assessed using a visual analogue scale (VAS) and WOMAC index. Efficacy and safety by investigator and patient, and rescue medication, as an indirect measure of pain, were also recorded.

Results

A significant reduction in joint pain, stiffness and functional disability compared with baseline was observed at every follow-up visit (m>Pm><.001). Joint function improved by 38.7%on Day 30, reaching 47.5%on Day 180. Rescue medication use decreased from 58.2%at baseline to 2.5%on Day 90, increasing in the last visits. Efficacy and safety were positively evaluated by investigators and patients. No serious adverse events were observed. Mild side effects were reported in 4 patients (local pain and swelling in the infiltration area).

Discussion

There is evidence that repeated intra-articular injections of HA improve symptoms in KOA. However, studies with a single injection of HA have shown mixed results. This study demonstrates that one single intra-articular injection of non-cross-linked HA reduces joint pain and increases function in patients with KOA over a period of at least 6 months.