CSF tau markers are correlated with hippocampal volume in Alzheimer's disease

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• 作者：Leonardo C. de Souza^a ; ^b ; ^c ; ^d ; ^{leocruzsouza@hotmail.com} ; Marie Chupin^a ; ^b ; ^c ; Foudil Lamari^e ; Claude Jardel^a ; ^b ; ^c ; ^e ; Delphine Leclercq^a ; ^f ; Olivier Colliot^a ; ^b ; ^c ; Sté ; phane Lehé ; ricy^a ; ^b ; ^c ; ^f ; Bruno Dubois^a ; ^b ; ^c ; ^d ; Marie Sarazin^a ; ^b ; ^c ; ^d
• 关键词：Alzheimer's disease ; CSF biomarkers ; Hippocampus
• 刊名：Neurobiology of Aging
• 出版年：2012
• 期刊代码：202_01974580
• 类别：med
• 出版时间：July, 2012
• 卷：33
• 期：7
• 页码：1253-1257
• 文件大小：539 K

摘要

Hippocampal atrophy as assessed by magnetic resonance imaging (MRI) and abnormal cerebrospinal fluid (CSF) biomarkers are supportive features for the diagnosis of Alzheimer's disease (AD) and are assumed to be indirect pathological markers of the disease. In AD patients, antemortem MRI hippocampal volumes (HVs) correlate with the density of neurofibrillary tangles (but not with senile plaques) at autopsy suggesting that HVs may better correlate with CSF tau and hyperphosphorylated tau (P-tau) levels than CSF amyloid beta protein (A尾)₄₂ level. Here, we tested this hypothesis in a well-defined AD group. Patients were selected according to the New Research Criteria for AD, including specific episodic memory deficit and CSF AD profile (defined as abnormal ratio of A尾₄₂:tau). MRI was performed within 6 months of lumbar puncture. HVs were obtained using automated segmentation software. Thirty-six patients were included. Left HV correlated with CSF tau (R = 鈭?.53) and P-tau (R = 鈭?.56) levels. Mean HVs correlated with the CSF P-tau level (R = 鈭?.52). No correlation was found between any brain measurement and CSF A尾₄₂ level. The CSF tau and P-tau levels, but not the CSF A尾₄₂ level, correlated with HV, suggesting that CSF tau markers reflect the neuronal loss associated with the physiopathological process of AD.