An efficient synthesis of N-substituted indoles from indoline/indoline carboxylic acid via aromatization followed by C-N cross-coupling reaction by using nano copper oxide as a recyclable catalyst

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• 作者：K. Harsha Vardhan Reddy ; G. Satish ; K. Ramesh ; K. Karnakar ; Y.V.D. Nageswar ; ^{dryvdnageswar@gmail.com}
• 关键词：N-substituted indoles ; Indoline/indoline carboxylicacid ; CuO nanoparticles ; C&ndash ; N cross-coupling ; Recyclability
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：13 June, 2012
• 卷：53
• 期：24
• 页码：3061-3065
• 文件大小：6627 K

摘要

A new and elegant protocol for the synthesis of 1-substituted indoles was developed via aromatization of indoline/indoline carboxylic acid followed by C-N cross-coupling with various aryl halides in the presence of nano CuO as a recyclable catalyst, Cs₂CO₃ as a base in DMSO at 80 掳C. 1-Substituted indoles were obtained in good to excellent yields and the catalytic system can be recycled up to four cycles without loss of catalytic activity.