Associations between CYP1A1 and CYP2E1 polymorphisms and susceptibility to esophageal cancer in Chaoshan and Taihang areas of China

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• 作者：Dianliang Wang^a ; ^b ; ^{dianliangwang@yahoo.com} ; Min Su^a ; ^{sumin@stu.edu.cn} ; Dongping Tian^a ; Shuang Liang^a ; Jing Zhang^a
• 关键词：CYP1A1 ; CYP2E1 ; Esophageal cancer ; Genetic polymorphism ; Cancer susceptibility
• 刊名：Cancer Epidemiology
• 出版年：2012
• 期刊代码：P71_18777821
• 类别：med
• 出版时间：June, 2012
• 卷：36
• 期：3
• 页码：276-282
• 文件大小：596 K

摘要

Purpose: To study the causes of esophageal cancer in Chaoshan and Taihang areas. Methods: By using gel-based DNA microarray genotyping method, four cancer-related polymorphisms including CYP1A1 m2, CYP1A1 m4, CYP2E1 Pst I and CYP2E1 Rsa I were studied with 565 (CYP1A1) or 482 (CYP2E1) cases and 468 (CYP1A1) or 466 (CYP2E1) controls. Results: For CYP1A1 m2, the mutant allele frequencies were 21.3%(Chaoshan) and 19.6%(Taihang), and OR for AG versus AA genotype (Chaoshan) was 1.855 (95%CI [1.227-2.805]). For CYP1A1 m4, no mutant allele was detectable. For CYP2E1 Pst I, the mutant allele frequencies were 27.3%(Chaoshan) and 29.4%(Taihang), and OR for GG versus CC genotype (Taihang) was 3.263 (95%CI [1.059-10.052]). For CYP2E1 Rsa I, the mutant allele frequencies were 27.3%(Chaoshan) and 29.6%(Taihang), and OR for CC versus TT genotype (Taihang) was 3.167 (95%CI [1.026-9.776]). Conclusion: The results suggest that AG genotype of CYP1A1 in Chaoshan area and GG (CC) genotype of CYP2E1 in Taihang area are significantly associated with esophageal cancer susceptibility.