Effect of short-term interferon-尾 treatment on cytokines in multiple sclerosis: Significant modulation of IL-17 and IL-23

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• 作者：Murat Kü ; rtü ; ncü ; ^a ; Erdem Tü ; zü ; n^b ; ^{drerdem@yahoo.com} ; Recai Tü ; rko臒lu^c ; Belgin Petek-Balc谋^d ; Sema 陌ç ; ö ; z^e ; Mü ; nevver Pehlivan^e ; Ö ; mer Biri艧ik^e ; Canan Ulusoy^b ; Erkingü ; l Shugaiv^e ; Gü ; l艧en Akman-Demir^f ; Mefkü ; re Eraksoy^e
• 关键词：Multiple sclerosis ; Cytokine ; Interleukins ; Th17 ; Th1
• 刊名：Cytokine
• 出版年：2012
• 期刊代码：97_10434666
• 类别：imm
• 出版时间：August, 2012
• 卷：59
• 期：2
• 页码：400-402
• 文件大小：243 K

摘要

Therapeutic effect of interferon-尾 (IFN-尾) treatment has been associated with modulation of the balance between Th1, Th17, Th2 and regulatory T (Treg) cells, whereas the impact of disease modifying drugs on Th9-immunity in multiple sclerosis (MS) has not been studied. To investigate the short-term effects of IFN-尾 treatment on cytokines in MS, we determined serum levels of IL-17, IL-23, IL-10, IL-4, IFN-纬, IL-9 and TGF-尾 in relapsing remitting MS patients before and 2 months after IFN-尾 treatment by ELISA. MS patients showed increased IL-17, IL-23 and IL-4 levels and decreased IL-9 levels as compared to healthy controls. IFN-尾 treatment only reduced IL-17 and IL-23 levels, whereas the levels of other cytokines remained unchanged. IFN-尾 treatment appears to exert its earliest therapeutic effect on Th17-immunity. The influence of IL-9 on MS pathogenesis needs to be further studied.