Administration of hepatitis A vaccine at 6 and 12 months of age concomitantly with hexavalent (DTaP–IPV–PRPT–HBs) combination vaccine

详细信息	查看全文 | 推荐本文 |

• 作者：S. Stojanov ; J.G. Liese ; B.H. Belohradsky ; C. V ; ermeulen ; K. Hoppenbrouwers ; M. Van der Wielen ; P. Van Damme ; B. Georges ; M. Dupuy ; M. Scemama ; M. Watson ; A. Fiquet ; J.E. Stek ; G.T. Golm ; F.P. Sch
• 关键词：Hepatitis A ; VAQTA^® ; ; Hexavalent ; HEXAVAC^® ; ; Concomitant use ; Immunization ; Infant ; Vaccines
• 刊名：Vaccine
• 出版年：2007
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：23 October 2007
• 卷：25
• 期：43
• 页码：7549-7558
• 文件大小：163 K

摘要

Administration of two doses of hepatitis A (HA) vaccine to children ≥2 years of age has been shown to be protective. The present study assessed whether HA vaccine can be administered as early as 6 months of age and whether it can be administered concomitantly with a hexavalent (HV) vaccine at this age.

Methods

In an open label, randomized, parallel group study, the liquid HV vaccine (HEXAVAC^®) (diphtheria, tetanus, 2-component acellular pertussis, inactivated poliomyelitis vaccine, Haemophilus influenzae type b conjugated to tetanus protein and hepatitis B) was administered at 2, 4, 6, and 12 months of age to all children. HA vaccine (VAQTA^®) was given at 7 and 13 months in the separate administration group (Group 1) and at 6 and 12 months in the concomitant administration group (Group 2). Serum samples were obtained at 2, 7, 12, and 14 months in Group 1 and at 2, 7, 12, and 13 months in Group 2. The primary immunogenicity outcomes were the seroconversion rates for HA 1 month after the second dose of HA vaccine in initially seronegative subjects, and the seroconversion rates for each HV antigen 1 month after the third dose of the HV vaccine (both at 7 months of age).

Results

HA seropositivity rates 1 month after the second dose were 100%in both groups, regardless of initial serostatus. The responses to each HV antigen 1 month after the third dose were similar in both groups. The vaccines were generally well tolerated in both groups regardless of vaccine(s) administered.

Conclusions

A schedule of two doses of HA vaccine, 6 months apart beginning at 6 months of age is highly immunogenic and well tolerated when administered alone or concomitantly with HV vaccine at 6 and 12 months of age.