Dechlorination of the dietary nona-chlorinated toxaphene congeners 62 and 50 into the octa-chlorinated toxaphene congeners 44 and 40 in zebrafish (Danio rerio) and Atlantic salmon (Salmo salar)
- 作者：M.H.G. Berntssen ; marc.berntssen@nifes.no ; A.-K. Lundebye ; L. Hop-Johannessen ; E.-J. Lock
- 关键词：Toxaphene ; Parlar ; Atlantic salmon ; Zebrafish ; Biotransformation ; Dechlorination
- 刊名：Aquatic Toxicology
- 出版年：2012
- 期刊代码：19_0166445x
- 类别：abs
- 出版时间：15 May, 2012
- 卷：112-113
- 期：Complete
- 页码：54-61
- 文件大小：752 K
摘要
The relative feed-to-fish accumulation and possible biotransformation of the nona-chlorinated toxaphene congeners currently included in EU-legislation (CHB-50 and -62) and the octa-chlorinated congeners recommended by the European Food Safety Authority to be included in future surveillance of fish samples (CHB-40, 41, and 44) were investigated in the present study. Model fish Danio rerio were fed either (a) diets spiked with a combination as well as the pure individual toxaphene congeners CHB-50 or 62 or (b) diets spiked with the combination of CHB 鈭?0 + 62 and/or CHB 鈭?0 + 41 + 44. In addition, seawater adapted Atlantic salmon smolts were fed technical toxaphene enriched feeds for 62 days. Zebrafish fed a diet containing CHB-50 and CHB-62 accumulated newly formed CHB-40&41 and CHB-44, respectively. The biomagnifications factors (BMF) of the toxaphene congeners in Atlantic salmon muscle from the feeds spiked with technical toxaphene were significantly correlated with their relative lipophilicity (expressed as log Kow). An exception was CHB-44 which had a higher BMF than could be expected from its specific log Kow, reflecting that CHB-44 is a metabolite formed under dietary exposure to CHB-62. This paper reports the in vivo dechlorination of nona-chlorinated toxaphene congeners into octa-chlorinated congeners in feeding trials with a model fish (zebrafish) and an oily food fish (Atlantic salmon).