Histone deacetylase inhibition restores cisplatin sensitivity of Hodgkin's lymphoma cells

详细信息	查看全文 | 推荐本文 |

• 作者：Stefanie Kewitz ; Toralf Bernig ; Martin S. Staege ; ^{martin.staege@medizin.uni-halle.de}
• 关键词：Hodgkin's lymphoma ; Histone deacetylase inhibitors ; Gene expression ; Interleukin-26 ; Cisplatin resistance
• 刊名：Leukemia Research
• 出版年：2012
• 期刊代码：186_01452126
• 类别：med
• 出版时间：June, 2012
• 卷：36
• 期：6
• 页码：773-778
• 文件大小：568 K

摘要

Increasing evidence suggest that epigenetic mechanisms (e.g. histone modification by histone deacetylases) play a major role in the pathogenesis of Hodgkin's lymphoma (HL). We treated HL cell lines with the histone deacetylase inhibitor vorinostat and investigated the gene expression profile of these cells by using DNA microarrays. Vorinostat inhibited cell proliferation and induced chances in the gene expression profile of HL cells, including down regulation of interleukin-26 and CD30. Vorinostat also increased sensitivity for cisplatin. Our data suggest that the combination of vorinostat and chemotherapy might be an interesting option for patients with chemoresistant HL.