Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
- 作者：Shawcross ; Debbie L. ; Davies ; Nathan A. ; Williams ; Roger ; Jalan ; Rajiv
- 关键词：Minimal hepatic encephalopathy ; Neuropsychological function ; Proinflammatory cytokines ; Amino-acid solution ; aa ; amino acid ; BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; HE ; hepatic encephalopathy ; IL-6 ; interleukin 6 ; IL-1β ; interleu
- 刊名：Journal of Hepatology
- 出版年：2004
- 期刊代码：162_01688278
- 类别：med
- 出版时间：February, 2004
- 卷：40
- 期：2
- 页码：247-254
- 文件大小：188 K
摘要
Studies in acute liver failure show correlation between evidence of a systemic inflammatory response syndrome (SIRS) and progression of hepatic encephalopathy (HE). We tested the hypothesis that SIRS mediators, such as nitric oxide and proinflammatory cytokines, may exacerbate the neuropsychological effects of hyperammonemia in cirrhosis.