5-HT₂- and D₁-mechanisms of the basolateral nucleus of the amygdala enhance conditioned fear and impair unconditioned fear

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• 作者：Carlos Eduardo Macedo ; Raquel Chacon Ruiz Martinez ; Lucas Albrechet-Souza ; Victor Alej ; ro Molina ; Marcus Lira Br ; ã ; o
• 关键词：5-HT ; Dopamine ; Inferior colliculus ; Basolateral amygdala ; Unconditioned fear ; Conditioned fear
• 刊名：Behavioural Brain Research
• 出版年：2007
• 期刊代码：3_01664328
• 类别：neu
• 出版时间：12 February 2007
• 卷：177
• 期：1
• 页码：100-108
• 文件大小：744 K

摘要

The inferior colliculus (IC) is involved in processing of auditory information, but also integrates acoustic information of aversive nature. In fact, chemical stimulation of the IC with semicarbazide (SMC) – an inhibitor of the GABA synthesizing enzyme glutamic acid decarboxylase – has been found to cause defensive behavior in an open-field test and functions as an unconditioned stimulus in the place conditioned aversion test (PCA). A question has arisen regarding whether the basolateral nucleus of the amygdala (BLA) is involved in the acquisition of the aversive information ascending from the IC and whether dopaminergic and serotoninergic mechanisms of the BLA regulate this process. Recent evidence has shown that inactivation of the BLA with muscimol inhibits the PCA and causes an increase in the aversiveness of the chemical stimulation of the IC. Based on this, we examined the effects of ketanserin and SCH-23390, antagonists of the 5HT₂ and D₁ receptors, respectively, on the conditioned and unconditioned fear elicited by IC stimulation with SMC. The results obtained confirm the crucial role of 5-HT₂- and D₁-mechanisms of the BLA on conditioned fear in that ketanserin and SCH-23390 injections into the BLA caused a reduction in the PCA. On the other hand, ketanserin and SCH-23390 injections into the BLA enhanced the aversiveness of the IC injections of SMC. These findings suggest that while 5-HT₂ and DA₁ mechanisms in the BLA appear to facilitate the conditioned fear they inhibit the unconditioned fear triggered by IC activation.