Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations

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• 作者：Laura P. Serwer^a ; ^b ; C. David James^a ; ^{david.james@ucsf.edu}
• 关键词：Convection-enhanced delivery ; CED ; Intrathecal ; Intranasal ; Glioma ; Glioblastoma ; Liposome ; Chemotherapy
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2012
• 期刊代码：2_0169409x
• 类别：bio
• 出版时间：15 May, 2012
• 卷：64
• 期：7
• 页码：590-597
• 文件大小：513 K

摘要

The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption.