A new investigation for some steroidal derivatives as anti-Alzheimer agents

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• 作者：Mohamed M. Abdalla^a ; Mohamed A. Al-Omar^b ; ^c ; Rashad A. Al-Salahi^b ; Abdel-Galil E. Amr^c ; ^d ; ^{aamr1963@yahoo.com} ; Nermien M. Sabrye^e
• 关键词：Alzheimer's disease ; 尾-Amyloid (A尾) ; Steroidal derivatives ; Flurbiprofen
• 刊名：International Journal of Biological Macromolecules
• 出版年：2012
• 期刊代码：62_01418130
• 类别：abs
• 出版时间：July-August, 2012
• 卷：51
• 期：1-2
• 页码：56-63
• 文件大小：372 K

摘要

We herein report the anti-Alzheimer activity of some synthesized heterocyclic pyrimidine and thiopyrimidine derivatives fused with steroidal structure. Twenty-one of these compounds were synthesized and conveniently screened for their anti-Alzheimer activities using of Flurbiprofen as the reference drug. Some of these compounds were demonstrated to exhibit remarkable activity and their 尾-amyloid (A尾) lowering results as IC₅₀ values reported.