Electrocortical and behavioral responses produced by acute electrical stimulation of the human centromedian thalamic nucleus
- 作者：Velasco ; Marcos ; Velasco ; Francisco ; Velasco ; Ana Luisa ; Brito ; Francisco ; Jimé ; nez ; Friacro ; et. al.
- 关键词：Centromedian thalamic nucleus ; Reticular thalamo-mesencephalic systems ; Recruiting and augmenting responses ; EEG desynchronization and slow negative shift ; Spike-wave-complexes ; Typical absence responses
- 刊名：Electroencephalography and Clinical Neurophysiology
- 出版年：1997
- 期刊代码：84_00134694
- 类别：med
- 出版时间：June, 1997
- 卷：102
- 期：6
- 页码：461-471
- 文件大小：988 K
摘要
Incremental, desynchronizing and spike-wave electrocortical responses and concomitant symptoms to acute electrical stimulation of the centromedian thalamic nucleus (CM) were studied in 12 patients with intractable complex partial and tonic-clonic generalized seizures. Low-frequency (6/s), 320-800 μA stimulation of the caudal-basal and central portions of CM elicited incremental recruiting and augmenting-like responses with a bilateral regional scalp distribution, with emphasis at the ipsilateral frontal (recruiting) and central (augmenting) regions, while ventral-basal CM stimulation elicited primary-like responses with a focal distribution at the ipsilateral parietal region. High-frequency (60/s), 320-800 μA stimulation of caudal-basal and central, but not ventral-basal CM, elicited EEG desynchronization and a slow negative shift of the EEG baseline with scalp distribution similar to that showed by recruiting- and augmenting-like responses. Neither incremental nor desynchronization EEG responses were accompanied by evident patient sensory or motor responses. Low-frequency (3/s), high-intensity (30 V = 2400 μA) combined stimulation of the right CM and left non-specific mesencephalic ascending pathways elicited a response similar to the typical absence attack with all EEG and clinical ingredients: S1, S2, P1 and W components of the individual spike-wave complex and generalized spike-wave discharges followed by sleep spindle EEG afterdischarges, accompanied by motionless stare, 3/s eye blinking, lip smacking and total failure to respond to visual stimuli in patients under a simple responding task.