The design of this study was literature review and commentary. Selected articles from PubMed (except one) including both developing and developed countries regarding the patients鈥?survival in retinoblastoma were considered and reviewed critically. An analysis of 47 articles was performed. In conclusion, in spite of an obvious contrast of retinoblastoma survival disparity in the world, the expanding horizons in developing countries are promising and continuing on all fronts and results are hope-inspiring.