• 作者：Miguel &#193 ; ngel Garcí ; a Cabezas^a ; ^{partisanocabezas@gmail.com} ; Patricio Giralt Mui1 ; a^b ; Bá ; rbara Ferná ; ndez Valle^a ; Pedro Benito Ló ; pez^c
• 关键词：Diabetes mellitus de tipo 1 ; Haplotipos DQ ; Infancia
• 刊名：Medicina Cl铆nica
• 出版年：2010
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：3 April 2010
• 卷：134
• 期：9
• 页码：381-385
• 文件大小：245 K

Background and Objetive

Our hypothesis is that there is a relationship between the short term outcomes of pediatric patients with type I diabetes mellitus and their HLA-DQ genotypes.

Patients and Method

We performed a descriptive epidemiologic study of 129 children and adolescents under 16 years old with type 1 diabetes mellitus. We studied their HLA DQ genotypes and classified them into groups of diabetogenic risk. We studied general clinic and analytic parameters at onset of the disease and during a period of 3 years, and the development of associated chronic complications.

Results

In total, 93.8%of our patients had diabetes-risk HLA-DQ genotypes. Onset of the disease occurred earlier in patients who belonged to risk group III, and they had less pancreatic reserve. During the follow-up period, significant differences in systolic and diastolic blood pressure were found in patients in risk group III, and in diastolic blood pressure in patients in risk group I.

Conclusions

Patients in risk group III have an onset at a lower age and present significant differences in systolic and diastolic blood pressure during the follow up period.