Biotransformation of sophoricoside in Fructus sophorae by the fungus Schizophyllum commune

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• 作者：Jianguo Wu ; Xialu Yang ; Juan Ge ; Yiping Zhang ; Lin Wu ; Jianmiao Liu ; Xiaoyu Zhang ; ^{xyzhang.imer@gmail.com}
• 关键词：Schizophyllum commune ; Sophoricoside ; Fructus sophorae ; Biotransformation ; 4&prime ; 7-dihydroxy-5-methoxyisoflavone
• 刊名：Bioresource Technology
• 出版年：2012
• 期刊代码：11_09608524
• 类别：ce
• 出版时间：May, 2012
• 卷：111
• 期：Complete
• 页码：496-499
• 文件大小：212 K

摘要

Biotransformation of sophoricoside in Fructus sophorae was performed with Schizophyllum commune. Sophoricoside was firstly metabolized to 4鈥?5,7-trihydroxyisoflavone (2), and then to 4鈥?7-dihydroxy-5-methoxyisoflavone (3) and 5,7-dihydroxy-4鈥?methoxyisoflavone (4) as determined by NMR and MS analyzes. The content of compound (2) was increased by more than 30-fold, and compound (3) is a new product that showed good cytotoxic activity with an IC₅₀ of 12.1 nmol/ml against MCF-7 cells.