Specific and non-specific enzymes for furanosyl-containing conjugates: biosynthesis, metabolism, and chemo-enzymatic synthesis

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• 作者：Ilona Chlubnova ; Laurent Legentil ; Ré ; my Dureau ; Alizé ; Pennec ; Mé ; lanie Almendros^&dagger ; ; Richard Daniellou ; ^&Dagger ; ; Caroline Nugier-Chauvin ; Vincent Ferriè ; res ; ^{vincent.ferrieres@ensc-rennes.fr}
• 关键词：Hexofuranosyl-containing conjugates ; Enzymes ; Furanosides
• 刊名：Carbohydrate Research
• 出版年：2012
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：15 July, 2012
• 卷：356
• 期：Complete
• 页码：44-61
• 文件大小：1814 K

摘要

There is no doubt now that the synthesis of compounds of varying complexity such as saccharides and derivatives thereof continuously grows with enzymatic methods. This review focuses on recent basic knowledge on enzymes specifically involved in the biosynthesis and degradation of furanosyl-containing polysaccharides and conjugates. Moreover, and when possible, biocatalyzed approaches, alternative to standard synthesis, will be detailed in order to strengthen the high potential of these biocatalysts to go further with the preparation of rare furanosides. Interesting results will be also proposed with chemo-enzymatic processes based on nonfuranosyl-specific enzymes.