Pathological Findings in a Case of Equine T-Cell Lymphoma Associated with Ataxia

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• 作者：Takanori Ueno ; DVM ; PhD^a ; ^{ueno@center.equinst.go.jp} ; Shinya Wada ; DVM ; PhD^b ; Seigo Mashita ; DVM^b ; Atsutoshi Kuwano ; DVM ; PhD^a ; Yoshinari Katayama ; DVM ; PhD^c
• 关键词：Ataxia ; Epidural Space ; Equine ; T-Cell Lymphoma
• 刊名：Journal of Equine Veterinary Science
• 出版年：2012
• 期刊代码：173_07370806
• 类别：med
• 出版时间：June, 2012
• 卷：32
• 期：6
• 页码：315-319
• 文件大小：1500 K

摘要

A 15-year-old Dutch Warmblood gelding suddenly developed incoordination and hindlimb stumbling. The horse had a history of eyelid lymphoma. Necropsy revealed yellow-white or dark reddish-brown masses adhering to the outer surface of the spinal dura mater from the first cervical vertebra to the seventh thoracic vertebra. The spinal cord close to the first cervical vertebra and the seventh thoracic vertebra was markedly compressed by the masses filling the epidural space. The masses were also observed in the larynx, eyelids, and adipose-rich tissues, including the joints and orbits. They appeared similar in shape. The mandibular, retropharyngeal, axillary, superficial inguinal, deep inguinal, and lateral iliac lymph nodes were solid and enlarged. Histologically, the masses were composed of small or medium-sized lymphocyte-like tumor cells, but atypical cells and mitotic figures were rare. There were moderate infiltrations of macrophages and multinucleated giant cells, which were occasionally ingesting the surrounding tumor cells. Immunohistochemically, the tumor cells were classified as T-cell-derived cells. Throughout the spinal cord, enlargement or loss of nerve axons, dilation of periaxonal spaces, and macrophage infiltration into periaxonal spaces were observed, mainly in the ventral funiculus. Spinal cord compression by the tumor mass was suggested as a cause of the locomotive dysfunction. This is the first report of equine lymphoma with ataxia located from the proximal cervical to middle thoracic dura mater and in joint cavities.