LINGO1 and risk for essential tremor: Results of a meta-analysis of rs9652490 and rs11856808

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• 作者：F&eacute ; lix Javier Jim&eacute ; nez-Jim&eacute ; nez^a ; ^b ; ^{fjavier.jimenez@salud.madrid.org} ; ^{hortalon@yahoo.es} ; Elena Garcí ; a-Martí ; n^c ; Oswaldo Lorenzo-Betancor^d ; ^e ; Pau Pastor^d ; ^e ; ^f ; Hortensia Alonso-Navarro^a ; ^b ; Jos&eacute ; A.G. Agú ; ndez^g
• 关键词：Essential tremor ; Genetics ; LINGO1 polymorphisms ; Meta-analysis
• 刊名：Journal of the Neurological Sciences
• 出版年：2012
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：15 June, 2012
• 卷：317
• 期：1-2
• 页码：52-57
• 文件大小：890 K

摘要

Background/objectives

Recently, a genome-wide association study revealed a significant statistical association between LINGO1 rs9652490 and rs11856808 polymorphisms and the risk of developing essential tremor (ET) in Icelandic people. Because the results of further association studies were controversial, we conducted a meta-analysis including all the studies published on the risk of ET related with these polymorphisms.

Methods

The metaanalysis included 11 association studies between LINGO1 rs9652490 (3972 ET patients, 20,714 controls) and 7 association studies between LINGO1 rs11856808, and risk for ET (2076 ET patients, 18,792 controls), and was carried out by using the software Meta-Disc 1.1.1 (; Unit of Clinical Statistics, Hospital Ram贸n y Cajal, Madrid, Spain). Heterogeneity between studies in terms of degree of association was tested using the Q-statistic.

Results

Global diagnostic odds-ratios (ORs) and 95%confidence intervals (CI) for rs9652490 and rs11856808 of the total series were, respectively, 1.17 (1.00-1.36) (p = 0.069) and 1.20 (1.05-1.36) (p = 0.016). After excluding data on Icelandic people of the discovery series (that was responsible of a high degree of heterogeneity for rs9652490 polymorphism), the ORs and CI were 1.10 (0.97-1.26) (p = 0.063) and 1.12 (0.99-1.27) (p = 0.034). Global ORs and 95%CI for rs9652490 and rs11856808 of familial ET patients were, respectively, 1.27 (1.03-1.57) (p = 0.014) and 1.21 (1.10-1.44) (p = 0.031).

Conclusions

The results of the meta-analysis suggest a relationship between LINGO1 rs11856808 polymorphism and the risk for ET and for familial ET, while rs9652490 polymorphism was only related with the risk for familial ET.