Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results
- 作者：Giovanni Mantovani ; Antonio Macciò ; Clelia Madeddu ; Giulia Gramignano ; Roberto Serpe ; Elena Massa ; Mariele Dessì ; Francesca Maria Tanca ; Eleonora Sanna ; Laura Deiana ; Filomena Panzone ; Paolo
- 关键词：Cancer-related anorexia/cachexia syndrome and oxidative stress ; Proinflammatory cytokines ; Lean body mass ; Quality of life ; Medroxyprogesterone acetate ; Combined treatment approach
- 刊名：Nutrition
- 出版年：2008
- 期刊代码：81_08999007
- 类别：abs
- 出版时间：April 2008
- 卷：24
- 期：4
- 页码：305-313
- 文件大小：128 K
摘要
In April 2005 a phase III randomized study was started to establish which was the most effective and safest treatment of cancer-related anorexia/cachexia syndrome and oxidative stress in improving identified primary endpoints: increase of lean body mass, decrease of resting energy expenditure (REE), increase of total daily physical activity, decrease of interleukin-6 and tumor necrosis factor-
, and improvement of fatigue assessed by the Multidimensional Fatigue Symptom Inventory–Short Form (MFSI-SF).
, and improvement of fatigue assessed by the Multidimensional Fatigue Symptom Inventory–Short Form (MFSI-SF).