A novel liposome-encapsulated hemoglobin/silica nanoparticle as an oxygen carrier
- 作者：Mingxian Liu ; Lihua Gan ; ganlh@tongji.edu.cn ; Liuhua Chen ; Dazhang Zhu ; Zijie Xu ; Zhixian Hao ; Longwu Chen
- 关键词：LEHSN ; liposome-encapsulated hemoglobin/silica nanoparticle ; LEH ; liposome-encapsulated hemoglobin ; Hb ; hemoglobin ; SNs ; silica nanoparticles ; HIV ; human immunodeficiency virus ; W/O/W ; water-in-oil-in-water ; CTAB ; cetyltrimethylammonium bromide ; W/O ; wate
- 刊名：International Journal of Pharmaceutics
- 出版年：2012
- 期刊代码：24_03785173
- 类别：pha
- 出版时间：10 May, 2012
- 卷：427
- 期：2
- 页码：354-357
- 文件大小：826 K
摘要
A novel liposome-encapsulated hemoglobin/silica nanoparticle (LEHSN) was fabricated by a water-in-oil-in-water (W/O/W) double emulsion approach. Bovine hemoglobin (Hb) was first adsorbed onto the surfaces of silica nanoparticles (SNs), and then the complex of Hb/SNs was encapsulated by liposome to form LEHSN which has a core-shell supramolecular structure. On the one hand, liposomes built a cell membrane-like environment for the controlled release of Hb. On the other hand, SNs which act as rigid core provide a supported framework for lecithin membrane, and enhance the stability of liposomes. In comparison with liposome-encapsulated Hb (LEH), LEHSN shows substantially enhanced stability and improved release property of Hb in vitro. This study highlights the potential of the novel LEHSN as an oxygen carrier for pharmaceutical applications.