• 作者：Manuel F. Jimé ; nez-Navarro^a ; ^{jimeneznavarro@secardiologia.es} ; Francisco Jesú ; s Gonzá ; lez^b ; Juan Caballero-Borrego^a ; Juan Antonio Marchal^c ; Noela Rodrí ; guez-Losada^a ; ^b ; Esmeralda Carrillo^c ; José ; Manuel Garcí ; a-Pinilla^a ; José ; M. Herná ; ndez-Garcí ; a^a ; Rita Pé ; rez-Gonzá ; lez^b ; Gemma Ramí ; rez^d ; Antonia Ará ; nega^c ; Eduardo de Teresa Galvá ; n^a ; Investigadores RECAVA (Red Tem&aacute ; tica de Investigació ; n Cooperativa de Enfermedades Cardiovasculares)
• 关键词：Infarto agudo de miocardio ; Enfermedad coronaria aguda multivaso ; Enfermedad coronaria aguda monovaso ; Factor de crecimiento endotelial vascular ; Factor de crecimiento hepatocitario ; Fisiologí ; a ; Cé ; lulas progenitoras endoteliales
• 刊名：Revista Espa帽ola de Cardiolog铆a
• 出版年：2011
• 期刊代码：pca308_03008932
• 类别：med
• 出版时间：December 2011
• 卷：64
• 期：12
• 页码：1123-1129
• 文件大小：254 K

lass="h4">Introduction and objectives

Multivessel coronary disease is still a postinfarction prognostic marker despite new forms of reperfusion, such as primary angioplasty. The aim of this study was to determine the time sequence of various sets of endothelial progenitor cells and angiogenic cytokines (vascular endothelial growth factor, hepatocyte growth factor) according to the degree of extension of the postinfarction coronary disease.

lass="h4">Methods

We studied the release kinetics in 32 patients admitted for a first myocardial infarction with ST elevation, grouped according to whether they had single or multivessel disease, and 26 controls.

lass="h4">Results

The patients had a higher number of endothelial progenitor cells and angiogenic cytokines than the controls at all 3 measurements (admission, day 3, and day 7) of the following subsets: CD34, CD34+CD133+, CD34+KDR+, and CD34+CD133+KDR+CD45+(weak); this latter was higher on day 7. The levels of these cell subsets were all higher in the patients with single-vessel disease and at all 3 measurements. The vascular endothelial growth factor levels were raised during the first week and the hepatocyte growth factor showed an early peak on admission for infarction. No significant differences were seen in the cytokines according to coronary disease extension.

lass="h4">Conclusions

Although the release kinetics of different subsets of endothelial progenitor cells in patients with a first acute myocardial infarction with ST elevation was similar in those with single vessel disease to those with multivessel disease, the number of circulating endothelial progenitor cells was greater in the patients with single vessel disease. The vascular endothelial growth factor levels were raised during the first postinfarction week and the hepatocyte growth factor were higher on admission.

Full English text available from: