COMT Val¹⁵⁸Met genotype and the common basis of error and conflict monitoring

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• 作者：Roman Osinsky^a ; ^{roman.osinsky@uni-wuerzburg.de} ; Johannes Hewig^a ; Nina Alexander^b ; Jü ; rgen Hennig^c
• 关键词：Performance monitoring ; Dopamine ; COMT Val158Met ; ERN ; Conflict-N400
• 刊名：Brain Research
• 出版年：2012
• 期刊代码：8_00068993
• 类别：neu
• 出版时间：3 May, 2012
• 卷：1452
• 期：Complete
• 页码：108-118
• 文件大小：691 K

摘要

The present study investigated the possibility that different aspects of performance monitoring share a common dopaminergic foundation. For this purpose we analyzed the influence of the COMT Val¹⁵⁸Met polymorphism on electrophysiological markers of conflict and error monitoring, respectively. An EEG was recorded while 65 healthy subjects completed a response-conflict evoking task. In the event-related potential (ERP), both the conflict-N400 as well as the error-related negativity (ERN) were diminished in homozygous carriers of the Met allele. Moreover, the shared variance of both deflections was substantially explained by the COMT Val¹⁵⁸Met genotype. These findings suggest that the relation between error- and conflict-related processes in the medial frontal cortex is mediated by a common molecular mechanism, namely the individual magnitude of phasic dopaminergic transmission.