Europium-doped gadolinium sulfide nanoparticles as a dual-mode imaging agent for T₁-weighted MR and photoluminescence imaging

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• 作者：Jongjin Jung^a ; ¹ ; Mi Ae Kim^a ; ¹ ; Jee-Hyun Cho^b ; ^c ; ¹ ; Seung Jae Lee^a ; Ilseung Yang^d ; Janggeun Cho^b ; ^c ; Seong Keun Kim^d ; ^e ; Chulhyun Lee^b ; Joung Kyu Park^a ; ^{parkjk@krict.re.kr}
• 关键词：Europium-doped GdS nanoparticles ; Positive contrast agent ; MRI ; Fluorescence ; In vivo test
• 刊名：Biomaterials
• 出版年：2012
• 期刊代码：7_01429612
• 类别：ms
• 出版时间：August, 2012
• 卷：33
• 期：24
• 页码：5865-5874
• 文件大小：1930 K

摘要

We present a facile synthesis of europium-doped gadolinium sulfide (GdS:Eu³⁺) opto-magnetic nanoparticles (NPs) via sonochemistry. Their photoluminescence and strong paramagnetic properties enable these NPs to be utilized as an in聽vitro cell imaging and in聽vivo T₁-weighted MR imaging probe. The GdS:Eu³⁺ NPs have a prominent longitudinal (r₁) relaxivity value, which is a critical parameter for T₁-weighted MR imaging. Here, we showed not only their strong positive contrast effect to blood vessels and organs of mice, but also blood half-life and biodistribution including clearance from organs, in order to assess the GdS:Eu³⁺ NPs as a competent nanocrystal-based T₁ contrast agent. We further showed confocal images of breast cancer cells containing GdS:Eu³⁺ NPs to evaluate as a photoluminescence probe. Dual-mode imaging capability obtained from the GdS:Eu³⁺ NPs will allow target-oriented cellular imaging as well as the resulting disease-specific MR imaging.