Organic halogenated contaminants in mother-fetus pairs of harbor seals (Phoca vitulina richardii) from Alaska, 2000-2002

详细信息	查看全文 | 推荐本文 |

• 作者：Dongli Wang^a ; ¹ ; Shannon Atkinson^b ; Anne Hoover-Miller^b ; ^c ; Weilin L. Shelver^d ; Qing X. Li^a ; ^{qingl@hawaii.edu}
• 关键词：Persistent organic pollutants ; Harbor seals ; Maternal transfer
• 刊名：Journal of Hazardous Materials
• 出版年：2012
• 期刊代码：50_03043894
• 类别：ce
• 出版时间：15 July, 2012
• 卷：223-224
• 期：Complete
• 页码：72-78
• 文件大小：564 K

摘要

This study measured organochlorine pesticides (OCPs) including hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), heptachlor and dichlorodiphenyltrichloroethanes (DDTs), polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs) and polybrominated diphenyl ethers (PBDEs) in tissues of six mother-fetus pairs of harbor seals that were hunted for subsistence in Alaska waters of the Northern Pacific Ocean. These data suggest that significant amounts of these contaminants were transferred from mother harbor seals to fetuses during pregnancy and distributed among fetal organs. The tissue distribution depended on the chemical groups, the specific compounds in the groups and the target organs. Concentration profiles of 鈭慜CPs, 鈭慞CBs, 鈭慞CNs and 鈭慞BDEs were remarkably similar among maternal blubber, liver, and placenta, fetal blubber, and liver (except for HCHs), possibly indicating that the placenta did not serve as a barrier for all of the compounds analyzed. DDTs, HCB, HCHs, PCBs and PBDEs could penetrate the placenta and accumulate in the blubber of the fetus in utero, while HCHs, PCBs and PBDEs penetrated the placenta and accumulated more preferentially in the fetal liver than in the fetal brain in comparison with DDTs and HCB. Heptachlor and PCNs penetrated the placenta and accumulated in the fetal liver and brain instead of fetal blubber. Similar maternal transfer trends for OCPs, PCBs, PCNs and PBDEs were shown by fetal to maternal (FM) blubber ratios and FM liver ratios. Prenatal transfer of these toxic contaminants from mothers to fetus presumably through the placenta may pose health risks to the fetus during early development.