New MultiPEG-conjugated theophylline derivatives: Synthesis and pharmacological evaluations

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• 作者：Marina Zacchigna ; Gabriella Di Luca ; Francesca Cateni ; Vener ; o Maurich ; Maurizio Ballico ; Gian Maria Bonora ; Sara Drioli
• 关键词：Conjugation ; MultiPEG ; Polymers ; Prodrug
• 刊名：European Journal of Pharmaceutical Sciences
• 出版年：2007
• 期刊代码：15_09280987
• 类别：pha
• 出版时间：March 2007
• 卷：30
• 期：3-4
• 页码：343-350
• 文件大小：619 K

摘要

The successful conjugation of active theophylline molecules to two new multifunctional high-molecular weight poly(ethylene glycol) derivatives (MultiPEG) and their pharmacokinetic evaluations are reported. The drug loading was increased up to six times in comparison with commercial PEG of the same molecular weight. A clear increase of the time of persistence within the body and a concomitant improvement of the overall pharmacokinetic properties of those prodrugs were also observed. These studies sustain the use of these new PEG-based polymeric supports as a valuable alternative for an effective drug delivery system.