New copper(I) phosphane complexes of dihydridobis(3-nitro-1,2,4-triazolyl)borate ligand showing cytotoxic activity

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• 作者：Cristina Marzano ; Maura Pellei ; Simone Alidori ; Andrea Brossa ; Giancarlo Gioia Lobbia ; Francesco Tisato and Carlo Santini
• 关键词：Copper(I) complexes ; Scorpionate ligands ; Cytotoxic activity ; Antitumor drugs
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2006
• 期刊代码：53_01620134
• 类别：ch
• 出版时间：February 2006
• 卷：100
• 期：2
• 页码：299-304
• 文件大小：154 K

摘要

New copper(I) complexes of the type [H₂B(tz^NO2)₂]Cu[PR₃]₂ (1–5), [H₂B (tz^NO2)₂]Cu[dppe] (6) and [H₂B(tz^NO2)₂]Cu[PR₃] (7, 8) have been synthesized from the reaction of CuCl, potassium dihydrobis(3-nitro-1,2,4-triazol-1-yl)borate, K[H₂B (tz^NO2)₂], and mono- or bi-dentate tertiary phosphanes. The complexes obtained have been characterized by elemental analyses and FT-IR in the solid state, and by NMR (¹H and ³¹P{¹H}) spectroscopy in solution. Selected complexes 1, 3 and 5 have also been tested against a panel of several human tumor cell lines in order to evaluate their cytotoxic activity. Complexes 1 and 5 showed IC₅₀ values appreciably lower than those exhibited by cisplatin, the most used metal-based antitumor drug. It is worth noting that all three tested Cu(I) complexes appear to be particularly effective against A549 carcinoma cells that are resistant to cisplatin treatment.