- 作者：Marta Ramí ; rez Lapausa ; mrlapausa@yahoo.com ; José ; Francisco Pascual Pareja ; Mariam Amer Pé ; rez ; José ; Luis Vidal Pé ; rez ; Arturo Noguerado Asensio
- 关键词：Tuberculosis multirresistente ; Tratamiento ; Evolució ; n ; Revisió ; n
- 刊名：Medicina Cl篓陋nica
- 出版年：2012
- 期刊代码：pca254_00257753
- 类别：med
- 出版时间：26 May, 2012
- 卷：138
- 期：15
- 页码：643-649
- 文件大小：365 K
Background and objective
Although progress has been made to reduce the global incidence of tuberculosis, the emergence of multidrug-resistant tuberculosis during the past decade threatens to limit these results. The aim of this study is to evaluate the geographic distribution, clinical and microbiological characteristics and outcomes of multidrug-resistant tuberculosis patients in Spain.
Patients and methods
Retrospective study between January 1998 and December 2010 of patients attended in Cantoblanco-La Paz Hospital Isolation Internal Medicine Unit.
Results
Forty-seven patients were studied, with a mean age of 36 years. There were 33 male. Sixty-four per cent were immigrants and the mean residence time in Spain was 12 months. Twenty-six patients (55.3%) were new cases. Patients were resistant to a median of 5 drugs (interquartile range [IQR] 3-7) and 3 patients had extensively drug-resistant tuberculosis. Cultures became negative after a median of 68.5 days (IQR 49.5-91.8). The median length of hospitalization was 2.75 months (IQR 1.3-4.6). They were treated during a median of 22.4 months (IQR 15.3-24.3). The overall success rate was 93%. A directly observed treatment was carried out in 79%of patients. Sixty-eight per cent patients presented side effects. In 75%of the cases the effects were mild and moderate with no need to replace the drug. Fourteen patients were followed up for a median of 40.5 months (IQR 7.4-55) and no clinical or bacteriological manifestation of disease was detected.
Conclusions
Most patients with multidrug-resistant tuberculosis can be cured with the use of appropriate and intensive regimens, management of side effects and implementation of strategies to improve adherence to treatment.