Age-related production of osteoclasts and the changes of serum levels of vascular endothelial growth factor (VEGF) and receptor activator for nuclear factor (NF)-魏B ligand (RANKL) in osteopetrotic (op/op) mice
- 作者：Masahide Motokawa ; motumo@hiroshima-u.ac.jp ; Natsumi Tsuka ; Masato Kaku ; Toshitsugu Kawata ; Tadashi Fujita ; Junji Ohtani ; Yayoi Matsuda ; Akiko Terao ; Kazuo Tanne
- 关键词：op/op mice ; VEGF ; RANKL ; Osteoclasts
- 刊名：Archives of Oral Biology
- 出版年：2012
- 期刊代码：25_00039969
- 类别：med
- 出版时间：April, 2012
- 卷：57
- 期：4
- 页码：352-356
- 文件大小：1530 K
摘要
Objective
Expression of osteoclasts in osteopetrotic (op/op) mice is substantially reduced by the absence of functional macrophage colony-stimulating factor (M-CSF). However, it has been reported that osteoclasts do gradually appear in the bones of op/op mice and spontaneously correct the osteopetrosis.Design
Age-related production of osteoclasts and the changes of serum levels of vascular endothelial growth factor (VEGF) and receptor activator for nuclear factor (NF)-魏B ligand (RANKL) in op/op mice were examined.
Results
The number of femoral osteoclasts, and the serum levels of VEGF, both gradually increased in op/op mice after birth and reached a peak in 120- and 60-day-old mice, respectively. However, the serum levels of RANKL showed an inverse relationship to osteoclast number.
Conclusions
These findings suggest that the appearance of osteoclasts may be influenced by the serum levels of VEGF and that the serum levels of RANKL may be influenced by the appearance of osteoclasts.