ETV6 fusion genes in hematological malignancies: A review

详细信息	查看全文 | 推荐本文 |

• 作者：Etienne De Braekeleer^a ; ^b ; ^c ; Nathalie Douet-Guilbert^a ; ^b ; ^c ; Fré ; dé ; ric Morel^a ; ^b ; ^c ; Marie-José ; e Le Bris^c ; Audrey Basinko^a ; ^b ; ^c ; Marc De Braekeleer^a ; ^b ; ^c ; ^{marc.debraekeleer@univ-brest.fr}
• 关键词：ETV6 ; Acute lymphoblastic leukemia ; Acute myeloblastic leukemia ; Fusion genes ; Myeloproliferative neoplasm ; Myelodysplastic syndrome
• 刊名：Leukemia Research
• 出版年：2012
• 期刊代码：186_01452126
• 类别：med
• 出版时间：August, 2012
• 卷：36
• 期：8
• 页码：945-961
• 文件大小：755 K

摘要

Translocations involving band 12p13 are one of the most commonly observed chromosomal abnormalities in human leukemia and myelodysplastic syndrome. Their frequently result in rearrangements of the ETV6 gene. At present, 48 chromosomal bands have been identified to be involved in ETV6 translocations, insertions or inversions and 30 ETV6 partner genes have been molecularly characterized. The ETV6 protein contains two major domains, the HLH (helix-loop-helix) domain, encoded by exons 3 and 4, and the ETS domain, encoded by exons 6 through 8, with in between the internal domain encoded by exon 5. ETV6 is a strong transcriptional repressor, acting through its HLH and internal domains. Five potential mechanisms of ETV6-mediated leukemogenesis have been identified: constitutive activation of the kinase activity of the partner protein, modification of the original functions of a transcription factor, loss of function of the fusion gene, affecting ETV6 and the partner gene, activation of a proto-oncogene in the vicinity of a chromosomal translocation and dominant negative effect of the fusion protein over transcriptional repression mediated by wild-type ETV6. It is likely that ETV6 is frequently involved in leukemogenesis because of the large number of partners with which it can rearrange and the several pathogenic mechanisms by which it can lead to cell transformation.