Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis

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• 作者：Yongqian Bian^a ; ¹ ; Li Wang^b ; ¹ ; Huanyu Lu^b ; ¹ ; Guodong Yang^b ; Zhang Zhang^a ; Haiyan Fu^b ; Xiaozhao Lu^b ; Mengying Wei^b ; Jianyong Sun^a ; Qingchuan Zhao^a ; Guanglong Dong^a ; ^c ; ^{gldong301@gmail.com} ; Zifan Lu^b ; ^{luzfliuq@fmmu.edu.cn}
• 关键词：Gastric cancer ; RNA binding protein QKI ; Methylation ; Prognosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：25 May, 2012
• 卷：422
• 期：1
• 页码：187-193
• 文件大小：685 K

摘要

Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. RNA-binding protein Quaking (QKI) is a newly identified tumor suppressor in multiple cancers, while its role in GC is largely unknown. Our study here aimed to clarify the relationship between QKI expression with the clinicopathologic characteristics and the prognosis of GC. In the 222 GC patients鈥?specimens, QKI expression was found to be significantly decreased in most of the GC tissues, which was largely due to promoter hypermethylation. QKI overexpression reduced the proliferation ability of GC cell line in vitro study. In addition, the reduced QKI expression correlated well with poor differentiation status, depth of invasion, gastric lymph node metastasis, distant metastasis, advanced TNM stage, and poor survival. Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival.