2-Aminopyridine derivative as fluorescence 鈥極n-Off鈥?molecular switch for selective detection of Fep>3+ p>/Hgp>2+ p>
- 作者：Rik Rani Koner ; Sougata Sinha ; Sunil Kumar ; Chayan K. Nandi
- 关键词：Fluorescence chemosensor ; Molecular switch ; Quenching ; Aminopyridine
- 刊名：Tetrahedron Letters
- 出版年：2012
- 期刊代码：109_00404039
- 类别：ch
- 出版时间：2 May, 2012
- 卷：53
- 期：18
- 页码：2302-2307
- 文件大小：874 K
摘要
2-Amino-6-methyl-4-phenyl-nicotinonitrile dFont">1, a 2-aminopyridine-based fluorescent compound, was found to be a fluorescent chemosensor for the detection of Fep>3+ p> and Hgp>2+ p> ions over a number of other metal ions. Compound dFont">1 was synthesized in one step using a multicomponent reaction, and characterized using common spectroscopic tools. During Fep>3+ p>/Hgp>2+ p> sensing the compound dFont">1 followed a 鈥榮witch-off鈥?mechanism. Further, compound dFont">1 could sense Fep>3+ p> over Hgp>2+ p> by its distinct absorption and fluorescence quenching behaviors. 1:1 complex formation of dFont">1 with Fep>3+ p> and Hgp>2+ p> was clearly understood from Job鈥檚 plot. The present work brings additional evidence on the importance of multicomponent reactions which could lead to the development of fluorescence chemosensor in one step for the selective detection of biologically important metal ions.